Vertigo (dizziness) was reported in some people who received Prolia for osteoporosis, but this was a less common side effect. Theyll need to confirm that you arent pregnant. Theyre commonly used to treat osteoporosis. such as inflammation of your skin (dermatitis), rash, and eczema have been reported. This medicine may cause jaw bone problems (osteonecrosis). They include bone pain, back pain, and a higher risk of certain infections. So, if you want to stop taking Prolia, talk with your doctor. Your body needs calcium to build and maintain strong bones. Your heart, muscles and nerves also need calcium to function properly. Some studies suggest that calcium, along with vitamin D, may have benefits beyond bone health: perhaps protecting against cancer, diabetes and high blood pressure. 1 shot every 6 months could mean fewer doses. If youd like to know more about the differences and similarities of Prolia and Evenity, see this comparison. So treatment with the drug requires you to take daily calcium and vitamin D supplements. Instead, your doctor may recommend that you make certain changes to your diet, such as increasing your calcium and vitamin D intake. They can also tell you about other treatment options available for osteoporosis and bone loss prevention. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Patient testimonials represent individual experiences with Prolia. Allergic reaction. In addition, you should use effective birth control while youre taking Prolia. They may also suggest exercises to help improve your bone strength and lower your risk for fractures and osteoporosis. Prescribing Information and Prolia isnt approved to treat osteopenia or arthritis. Your doctor or health care professional may order blood tests and other tests to see how you are doing. If you have any questions about Prolias side effects, talk with your doctor. Women going through menopause have a higher risk of developing osteoporosis. Prolia was the right choice for me because it worked for me and it was 1 shot every 6 months. How long will the side effects of Prolia last? You may wonder how Prolia compares with the alternative drug Reclast. may occur. Prolia has active ingredients of denosumab. Fatigue (low energy) and nausea werent specifically reported as side effects in clinical trials of Prolia. The Prolia is making my leg bones and jaw bones hurt. Generic name: denosumab (Prolia) [den-OH-sue-mab] Try to avoid being around people who are sick. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Any advice? (Chlorhexidine helps kill germs in your mouth.). Call your doctor right away if you have an allergic reaction to Prolia. If youre able to become pregnant, your doctor will order a pregnancy test for you before you take Prolia. If youre concerned about side effects with Prolia, talk with your doctor. Mild side effects that have been reported with Prolia include: These side effects may be temporary, lasting a few days or weeks. Before you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. Be sure to talk with your doctor about which medication is right for you. Factors to consider include those in the list below. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. This list doesnt include all possible mild side effects of the drug. You should also take calcium and vitamin D supplements while being Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Nonmetastatic means the cancer hasnt spread to other areas of the body. Tell your doctor about all other medicines you use. If youd like to learn more about Prolia, talk with your doctor or pharmacist. The drug could cause your calcium level to drop too low. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. Vitamin D The body needs vitamin D to absorb calcium. Denosumab is contraindicated in women with hypocalcaemia. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. In this article well discuss the uses, side effects, safety precautions, and other important information about Prolia. (2021). Prolia injections administered by a healthcare professional. The most common side effects of Prolia in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. Advertising on our site helps support our mission. An allergic reaction is possible after using Prolia. High cholesterol itself doesnt cause any symptoms. Common interactions include nausea among females and fatigue among males. Visit www.fda.gov/medwatch, orcall1-800-FDA-1088. If youre pregnant or breastfeeding, or considering either, talk with your doctor. High cholesterol levels can be a side effect of Prolia. They can recommend a treatment option other than Prolia. They need to know if you have any of these conditions: This medicine is for injection under the skin. Learn how to slow it down and fortify your body against it. There arent any studies that have compared these two drugs to each other. Mild side effects can occur with Prolia use. Youll receive Prolia from a healthcare professional as an injection under the skin in one of the following areas: Prolia contains the active drug denosumab, which is a biologic medication. Hair loss with Prolia is rare, and whether Prolia is responsible for this effect isnt known. Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. Calcium and Vitamin D: A major role of vitamin D is to help the body absorb calcium and maintain bone density. You may report side effects to FDA at 1-800-FDA-1088. Patients in the study may take other drugs besides Prolia and Calcium. BMD was increased by 8.8% at the lumbar spine, 6.4% at the total hip, and 5.2% at the femoral neck in trials that measured BMD after three years of treatment with Prolia. Tell your doctor right away if you become pregnant while taking Prolia. Patients should not stop Prolia treatment without first consulting your You should also talk with them if you have any serious side effects during Prolia treatment. Prolia is usually given once every 6 months. The risk is real, but rare. Before you have any dental work done, tell your dentist you are receiving this medicine. Tell them if you have any scheduled dental work coming up. For a detailed breakdown of Prolia versus Xgeva, check out this article. Breastfeeding. In certain cases, Prolia may have contraindications (not be recommended) for you due to a higher risk for side effects. Your doctor will order blood tests to check your level before you start using Prolia and regularly during your treatment. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. Prolia can also increase this risk. Some research has shown that alcohol consumption may increase your risk of osteoporosis, a bone fracture or impaired healing after a fracture. If you have more questions about what to expect with dental procedures while youre taking Prolia, talk with your doctor or dentist. Drug class: miscellaneous bone resorption inhibitors. These are serious. If youve had surgery on your thyroid or parathyroid glands, you may have an increased risk of a low level of calcium in your blood. Use effective birth control while using denosumab and for at least 5 months after your last dose. If youve already gone through menopause, your risk for bone loss is increased. Check with your doctor if you have more questions about these drugs. * Approximation only. But doing so can cause more bone breakdown and increase your risk for bone fractures. Talk with your doctor or health care professional about your birth control options while taking this medicine. Youll likely have questions about your condition and treatment choices. Some examples of these treatments include: Talk with your doctor about other drugs you may need to take with Prolia. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. Also tell them if you smoke, drink alcohol, or use illegal drugs. So, dont be afraid to ask questions or offer feedback on your treatment. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. Its possible that some of Prolias side effects may be long term, but theyre rare. Prolias manufacturer also provides some self-injection instructions, as well as a video to show you how to inject Prolia. But if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number. Do not use denosumab if you are pregnant. To help prevent low calcium, your healthcare provider may also With these reports, it wasnt known whether Prolia or something else (such as a different medication) caused the hair loss. Treating any mouth or dental problems early is the best way to help prevent serious dental complications. But before taking Prolia, be sure to tell your doctor about all medications you take (including prescription and over-the-counter types). Heres a short list of some of the mild side effects that Prolia can cause. The most common side effects of Prolia in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). Prolia also has other uses, which are described in the next section below. They can give you more details about this possible side effect and suggest ways to manage it. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. For more information about how Prolia and Zometa compare with each other, see this article. This is called hypocalcemia. But if youre planning to have surgery, you may need to take a break It may also be higher if you have dental work done while youre taking Prolia. Other drugs may interact with denosumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Terms of Use. If your Prolia treatment is stopped, talk to your doctor about other medicine that RA is an autoimmune condition in which your immune system attacks your joints. The phase IV clinical study analyzes what interactions people who take Prolia and Calcium have. Theyll discuss with you other treatments to help protect you from fractures and bone loss. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. What's the difference between Prolia and Reclast? Its a prescription drug thats used to treat osteoporosis and other forms of bone loss. What Health Changes Should You Expect Postmenopause? To learn how Prolia and Tymlos are alike and different, see this comparison. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Different individuals may respond to medication in different ways. Prolia is available as the biosimilar medication denosumab. You may have questions about Prolia and your treatment plan. But weight gain may be a symptom of a side effect called peripheral edema. Here are a few tips that might help guide your discussion: Remember, your doctor and other healthcare professionals are available to help you. Weakness and tingling can also occur. Prolia works by blocking osteoclasts (certain bone cells) from breaking down bone tissue in your body. Its given to adults who are at high risk for bone fractures. Please see Prolia full These types of medications come in forms that are taken by mouth and forms that are given by injection. If youre concerned about unexplained weight gain while using Prolia, talk with your doctor. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Calcium supplements may help support bone and teeth health. Tell your doctor if you become pregnant. Your risk for some health conditions increases when you are postmenopausal. Some rare side effects of Prolia can be serious and need medical attention. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. Talk with your doctor about the risks of using this drug during pregnancy. Bisphosphonates, on the other hand, help increase bone thickness and prevent bone breakdown. (Vitamin D helps your body absorb calcium.) They can explain the risks and benefits of this drug. Follow your doctor's instructions. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Prolia contains the active ingredient denosumab. Your doctor will explain how Prolia will be given to you. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. Continue reading. If youd like a detailed comparison of Prolia versus Boniva, view this article. To see a side-by-side comparison of Prolia and Fosamax, view this drug article. Talk with your doctor about your health history and discuss your risks with Prolia treatment. Prolia is an injection prescribed for certain adults with osteoporosis, which Side effects that you should report to your doctor or health care professional as soon as possible: Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): This list may not describe all possible side effects. This may help to protect healthy cells from damage. Doing so will help you avoid the risk for a low calcium level during treatment. Certain kidney problems, such as chronic kidney failure, can cause a low calcium level in your blood. You should always consult your doctor or another healthcare professional before taking any medication. You should not take Prolia if youve ever had an allergic reaction to Prolia or any of its ingredients. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are receiving this medicine. What are some frequently asked questions about Prolia? Specifically, Prolia is a monoclonal antibody (a lab-made protein). Take good care of your teeth and gums while you receive Prolia. Xgeva is another brand of denosumab that treats high calcium levels caused by cancer and prevents bone breaks. Stopping Prolia doesnt cause withdrawal symptoms. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. Its not known if Prolia is safe or effective for use in children. Your doctor may suggest limiting foods that are high in trans fats, such as fried foods. Youll receive 60 mg/mL of Prolia once every 6 months. It is advisable to take 2 capsules in the morning with food and 1 in the evening also with food. Specifically, Prolia works by blocking a protein called RANK. WebStudies have shown that people who live more sedentary lifestyles are at an increased risk of developing osteoporosis. if you are taking medicine that lower your blood calcium levels. These include osteonecrosis of the jawbone. If you have low calcium levels, you should not take Prolia. I am taking Prolia and just saw that it's important to take Calcium because Prolia takes the calcium out of the blood and that can cause problems. * For more information about this side effect, see Side effect specifics below. Be sure to read this information carefully each time. It comes as a liquid solution thats given as an injection. If you have low blood calcium, it may get worse during treatment. Prolia and Evenity are both biologic medications, but Prolia contains the active drug denosumab, while Evenity contains the active drug romosozumab-aqqg. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. Below are commonly used dosages, but the dosage you receive will be determined by your doctor. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Its thought that hair loss could occur due to how Prolia affects your immune system. Mild side effects of Prolia that have been reported include: Mild side effects of many drugs may go away within a few days or a few weeks. Learn about compression fractures, preventive medications, and, Preventing osteoporosis can help you prevent fractures and maintain strength as you age. It does the same thing that. Osteoporosis is a condition that weakens your bones, making them more susceptible to fractures. Its important to tell your doctor if you have serious or ongoing side effects. Use of the term female in this article refers to sex assigned at birth. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. Heres a sample meal plan thats packed with nutritious foods just for. 2023 Healthline Media LLC. Yoga is an excellent way to manage symptoms of osteoporosis. Do not shake the prefilled syringe. Prolia may cause several side effects. But certain choices and habits accelerate the process. Theyll do this with certain tests, such as a bone scan or ultrasound. Stopping some drugs leads to withdrawal symptoms because your body is used to the drug and needs it for you to feel normal. Do not stop, skip or delay taking Prolia without first talking with your doctor. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. You may report side effects to FDA at 1-800-FDA-1088. See additional information. WebDrug interactions are reported among people who take Prolia and Calcium. Continue reading, While there are no known drug interactions between Prolia (generic name: denosumab) and alcohol, but you should check with your doctor first before you drink. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.) These lists dont include all possible side effects. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.ada.org/en/member-center/oral-health-topics/osteoporosis-medications, https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125320s210lbl.pdf, New clues to slow aging? Prolia may lower the level of calcium in your blood. Your doctor or another healthcare professional will inject Prolia under the skin in one of the following areas: Prolia doses are given as an injection by healthcare professionals once every 6 months. Prolia may be used off-label for RA, if you have a high risk for bone fractures. No one in clinical trials of Prolia had to stop taking the drug due to dizziness. They have some similar uses and side effects, but they also have some differences. (To learn more, see the Side effect specifics section above.). Do not share this medicine with another person, even if they have the same symptoms you have. Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. MNT is the registered trade mark of Healthline Media. For instance: Both Prolia and Forteo are given as injections under your skin. Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. Youll receive Prolia doses from a healthcare professional. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. If your pain doesnt ease with OTC options, your doctor may suggest prescription pain medication. What do I need to be aware of if I need a tooth extraction while Im using Prolia? They can also suggest ways to relieve this side effect. Talk with your doctor about which medication is right for you. They may give you tips on managing a body weight thats healthy for you. They may want to check for other causes. You should talk with your doctor if you develop any mild side effects that concern you. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. To learn more about this, see the How is Prolia administered? section below. You may need to have a dental exam before you begin treatment with Prolia. Prolia and Xgeva both contain the active drug denosumab, but they are not approved to treat all of the same conditions. Call your doctor or health care professional if you are unable to keep an appointment. Find out why people need calcium, which foods provide it, and what happens if they consume. Its a, Forteos active ingredient is teriparatide. This is because the drug may be harmful to a growing fetus. The drug stays in your system and continues to slow bone breakdown over this period of time. Your dentist may have you use a chlorhexidine mouth rinse before and after surgery to reduce your risk for jaw-related side effects. This medicine is only given in a clinic, doctor's office, or other health care setting and will not be stored at home. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Brush and floss your teeth regularly while receiving this medication. In addition to treating osteoporosis, which is described just above, Prolia also has other uses. Your doctor can give you more information about the risks and benefits and how Reclast compares with Prolia. If you cant properly absorb calcium or other minerals, be sure to talk with your doctor before using Prolia.
